1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e]...

Details 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e]... 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e]...

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/519 (2006.01) A61P 25/16 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2717172

Compounds of the Formula I wherein R1 and R2 together with the carbon atoms to which they are bonded optionally form a further heteroaromatic ring of the formula (II) as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.

L'invention concerne: des composés de fomule (I), dans cette formule, R1 et R2,conjointement aux atomes de carbone ausquels ils sont liés, formant éventuellement un autre anneau hétéroaromatique de formule (II); ainsi que des sels, des solvates, des esters et des promédicaments pharmaceutiquement acceptables de tels composés, servant d'antagonistes aux récepteurs A2a de l'adénosine, et donc s'avérant utiles pour traiter des maladies du système nerveux central, et en particulier, la maladie de Parkinson.

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