1,2,4-trisubstituted benzenes as inhibitors of 15-lipoxygenase

Details 1,2,4-trisubstituted benzenes as inhibitors of 15-lipoxygenase 1,2,4-trisubstituted benzenes as inhibitors of 15-lipoxygenase

C - Chemistry, Metallurgy

07

D

C07D 209/14 (2006.01) A61K 31/33 (2006.01) A61P 43/00 (2006.01) C07D 209/48 (2006.01) C07D 213/30 (2006.01) C07D 295/08 (2006.01) C07D 295/088 (2006.01) C07D 333/16 (2006.01)

Patent

CA 2411495

The present invention provides compounds of formula (I) wherein R, Z, Y, W, R~5, V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the treatment of diseases responsive to the inhibition of the enzyme 15-lipoxygenase. Thus, the compounds of formula (I) and their pharmaceutically acceptable salts are useful for treating diseases with an inflammatory component, including atherosclerosis, diseases involving chemotaxis of monocytes, inflammation, stroke, coronary artery disease, asthma, arthritis, colorectal cancer, and psoriasis.

La présente invention concerne des composés correspondant à la formule (I), dans laquelle R, Z, Y, W, R5, V et X correspondent à la définition donnée dans la description, ainsi que des sels pharmaceutiquement acceptables de ces composés, lesquels sont utiles pour le traitement de maladies que l'on peut soigner par inhibition de l'enzyme 15-lipoxygénase. Ainsi, les composés correspondant à la formule (I) et leurs sels pharmaceutiquement acceptables sont utiles dans le traitement de maladies présentant une composante inflammatoire, y compris l'athérosclérose, des maladies impliquant le chimiotactisme de monocytes, les inflammations, l'apoplexie, les maladies artérielles coronariennes, l'asthme, l'arthrite, le cancer colorectal et le psoriasis.

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