1,2,5,6-tetrahydropyridine oxime derivatives

Details 1,2,5,6-tetrahydropyridine oxime derivatives 1,2,5,6-tetrahydropyridine oxime derivatives

C - Chemistry, Metallurgy

07

D

C07D 211/68 (2006.01) A61K 31/44 (2006.01) C07D 211/70 (2006.01) C07D 211/78 (2006.01) C07D 211/94 (2006.01) C07D 213/89 (2006.01)

Patent

CA 2093823

2093823 9206959 PCTABS00012 Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein R1 represents a 1,2,5,6-tetrahydropyridin-3-yl group N-substituted by R10 wherein R10 represents OH; a group hydrolysable in vivo to OH or hydrogen; C1-8 alkoxy; C2-8 alkenyloxy; C2-8 alkynyloxy; C3-8 cycloalkyloxy; or COR13 wherein R13 represents hydrogen, C1-8 alkyl, phenyl or phenyl C1-4 alkyl; in which any phenyl moiety is optionally substituted by up to 3 substituents independently selected from C1-6 alkoxy, C1-6 alkyl, halo, C1-6 alkoxycarbonyl, cyano, C1-6 alkylthio or C1-6 alkylsulphonyl; enhance acetylcholine function via an action at muscarinic receptors within the central nervous system and are therefore of potential use in the treatment and/or prophylaxis of dementia in mammals.

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