1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)-...

Details 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)-... 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)-...

C - Chemistry, Metallurgy

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C07D 487/04 (2006.01) A61K 31/40 (2006.01) C07D 498/04 (2006.01) C07D 498/10 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1238907

ABSTRACT OF THE DISCLOSURE 1,2,8,8a-Tetrahydrocyclopropa[3]pyrrolo(3,2-e)indol-4(5H)-ones, and related compounds of formulas I and intermediate therefor II Image I Image II wherein R2, R2', R3, R5, R50 and X are as defined in the specification, e.g.,(7bR,8aS)-1,2,8,8a-tetrahydro-7-methyl-2-[[5-(((1H-indol-2-yl)car- bonyl)amino)-1H-indol-2-yl]carbonyl]cyclopropa[pyrrolo[3,2-e]indol- 4(5H)-one (U-71,184), as purified, and its racemic form (U-68,415), and related compounds, are useful as ultraviolet light absorbers and as antibacterials. The lead compounds are useful as antitumor drug compounds in standard laboratory animal tests.

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