C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/207.7
C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 498/10 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01)
Patent
CA 1293248
ABSTRACT OF THE DISCLOSURE 1,2,8,8a-Tetrahydrocyclopropa[3]pyrrolo(3,2-e)indol-4(5H)-ones, and related compounds of formulas I and intermediate therefor II Image Image I II wherein R2, R2', R3, R5, R50 and X are as defined in the specification, e.g.,(7bR,8aS)-1,2,8,8a-tetrahydro-7-methyl-2-[[5-(((1H-indol-2-yl)car- bonyl)amino)-1H-indol-2-yl]carbonyl]cyclopropa[pyrrolo[3,2-e]indol- 4(5H)-one (U-71,184), as purified, and its racemic form (U-68,415), and related compounds, are useful as ultraviolet light absorbers and as antibacterials. The lead compounds are useful as antitumor drug compounds in standard laboratory animal tests.
552543
Kelly Robert Charles
Warpehoski Martha Anna
Wierenga Wendell
Macrae & Co.
Pharmacia & Upjohn Company Llc
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