C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/233, 260/305
C07D 233/56 (2006.01) C07D 249/08 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1241657
ABSTRACT The invention relates to a chemical compound of the formula Image (I), a pharmaceutically acceptable acid addition salt or a stereochemically isomeric forms thereof, wherein Q is CH or N; R is hydrogen, lower alkyl, aryl, aryllower alkyl or halo; and Ar is aryl; wherein aryl is phenyl, substituted phenyl, naphthalenyl, substituted naphthalenyl, thienyl or substituted thienyl, wherein. said substituted naphthalenyl and substituted thienyl are naphthalenyl, respectively thienyl, having 1 or 2 substituents each independently selected from the group consisting of halo, lower alkyl and lower alkyloxy and wherein said substituted phenyl is phenyl having from 1 to 3 substituents each independently selected from the group consis- ting of halo, lower alkyl, lower alkyloxy, trifluoromethyl, nitro, amino, phenyllower alkyl and a radical R2, said R2 being phenyl optionally substituted with halo and/or lower alkyl; provided that not more than one substituent on said substituted phenyl is a radical R2. 1-(2-aryl-2-halo-1-ethenyl)-1H-azoles having anticonvulsant properties which are particularly useful in the treatment of generalized forms of epilepsy. Processes for the production of these novel compounds of formula I are also described.
463356
Heeres Jan
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Naamloze Vennootschap
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