1,2-benzisoxazole derivatives, processes for their...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/00 (2006.01) A61K 31/42 (2006.01) A61K 31/445 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2029372

Compounds having formula I: (see fig. I) where m is a whole number from 0 to 5; n is a whole number from 1 to 2; p is equal to 0, 1 or 2; - X, Y and Z are identical or different and each represents one hydrogen atom, one halogen atom, one straight or branched aklyl radical, one trifluoromethyl radical, one alkoxy radical, one alkylthio radical or one hydroxy radical; - R represents one benzofuran-2-yl or 2,3-dihydrobenzofuran-2-yl radical (each substitutable on the benzene ring), one 2,3,6,7-tetrahydrobenzo[1,2-b:4,5b' -difuran-2-yl radical, one 4-oxo-4H-chromene-2-yl radical (possibly substituted on the benzene ring), one benzocyclobutenyl radical of formula A or one indanyl radical of formula B: Image (A) Image (B) (where R1 and R2 are identical or different and each represents one hydrogen atom, one halogen atom, one trifluoromethyl radical, one alkyl radical, one alkoxy radical, one hydroxy radical, one hydroxyalkyl radical, or one alkylthio radical, or else together they form one methylenedioxy radical, one ethylenedioxy radical, and R3 represents one hydrogen atom or one straight or branched alkyl radical with 1 to 6 atoms of carbon), or one radical of formula C: Image (C) (where R4, R5 and R6 are identical or different and each represents one hydrogen atom, one halogen atom, one trifluoromethyl radical, one hydroxy radical, one alkyl radical, one alkoxy radical or one alkylthio radical and R7 represents one hydrogen atom or one hydroxy radical), their optical isomers and their addition salts with an organic or inorganic acid which is pharmaceutically acceptable. Medications

Composés de formule I : (voir fig.I) dans laquelle - m représente un nombre entier de 0 à 5, n représente un nombre entier de 1 à 2, p est égal à 0, 1, ou 2, - X, Y et Z identiques ou différents représentent chacun un atome d'hydrogène, un atome d'halogène, un radical alkyle linéaire ou ramifié, un radical trifluorométhyle, un radical alcoxy, un radical alkylthio ou un radical hydroxy, - R représente un radical benzofuran-2-yle ou 2,3-dihydro benzofuran-2-yle (chacun pouvant être substitué sur le cycle benzénique), un radical 2,3,6,7-tétrahydro benzo[1,2-b:4,5b'] difuran-2-yl, un radical 4-oxo 4H-chromèn-2-yl (éventuellement substitué sur le cycle benzénique), un radical benzocyclobutènyle de formule A ou un radical indanyle de formule B : Image (A) Image (B) (dans lesquelles : R1 et R2 identiques ou différents représentent chacun un atome d'hydrogène, un atome d'halogène, un radical trifluorométhyle, un radical alkyle, un radical alcoxy, un radical hydroxy, un radical hydroxyalkyle, un radical alkylthio ou forment ensemble un radical méthylènedioxy, un radical éthylènedioxy, et R3 représente un atome d'hydrogène ou un radical alkyle linéaire ou ramifié de 1 à 6 atomes de carbone), ou un radical de formule C : Image (C) (dans laquelle R4, R5 et R6 identiques ou différents représentent chacun un atome d'hydrogène, un atome d'halogène, un radical trifluorométhyle, un radical hydroxy, un radioal alkyle, un radical alcoxy ou un radical alkylthio et R7 représente un atome d'hydrogène ou un radical hydroxy), leurs isomères optiques et leurs sels d'addition avec un acide organique ou minéral pharmaceutiquement acceptable. Médicaments

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