1,2-cyclohexylaminoaryl amides useful as analgesic agents

Details 1,2-cyclohexylaminoaryl amides useful as analgesic agents 1,2-cyclohexylaminoaryl amides useful as analgesic agents

C - Chemistry, Metallurgy

07

D

167/233, 260/306

C07D 295/155 (2006.01) A61K 31/40 (2006.01) C07D 295/135 (2006.01) C07D 307/79 (2006.01) C07D 307/88 (2006.01) C07D 405/00 (2006.01)

Patent

CA 2008391

Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents having very high kappa-opioid affinity and selectivity and potency and useful as analgesics, diuretics, antiinflammatory and psychotherapeutic agents are disclosed. Methods for making the compounds and pharmaceutical compositions containing them are also disclosed. These novel compounds are of the following general formula:

On divulgue de nouvelles 1,2-cyclohexylaminoarylamides utiles comme agents analgésiques ayant une affinité et une sélectivité très élevée pour les kappa-opioïdes et qui sont des agents puissants et utiles comme analgésiques, diurétiques, anti-inflammatoires et agents psychothérapeutiques. Des méthodes pour fabriquer les composés et des compositions pharmaceutiques contenant ces derniers sont également divulguées. Ces nouveaux composés ont la formule générale suivante :

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