1,2-di(cyclic)substituted benzene compounds

Details 1,2-di(cyclic)substituted benzene compounds 1,2-di(cyclic)substituted benzene compounds

C - Chemistry, Metallurgy

07

D

C07D 295/14 (2006.01) A61K 31/381 (2006.01) A61K 31/382 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) A61K 31/4418 (2006.01) A61K 31/451 (2006.01) A61K 31/4525 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/4965 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 207/06 (2

Patent

CA 2545999

A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. (see formula 1) (see formula 100) wherein R10 represents optionally substituted cycloalkyl, etc., R20- 23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.

L'invention concerne des composés représentés par la formule générale (1) ou (100), qui possèdent d'excellentes propriétés d'inhibition de l'adhérence cellulaire et de l'infiltration cellulaire, et sont utiles comme agents dans le traitement et la prévention de diverses maladies inflammatoires et auto-immunes provoquées par l'adhérence et l'infiltration des leucocytes, telles que des maladies inflammatoires de l'intestin (en particulier la rectocolite hémorragique ou la maladie de Crohn), le syndrome du côlon irritable, la polyarthrite rhumatoïde, le psoriasis, la sclérose en plaques, l'asthme et la dermatite atopique. Dans les formules, R<10> représente un cycloalkyle éventuellement substitué ou analogue ; R<20>, R<21>, R<22> représentent chacun hydrogène, alkyle, alcoxy ou analogue ; R<30>, R<31>, R<32> représentent chacun hydrogène, alkyle, oxo ou analogue ; et R<40> représente alkyle éventuellement substitué ou analogue.

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