C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/14 (2006.01) A61K 31/10 (2006.01) A61K 31/18 (2006.01) A61K 31/275 (2006.01) A61K 31/36 (2006.01) A61K 31/44 (2006.01) C07C 311/16 (2006.01) C07C 317/22 (2006.01) C07C 317/32 (2006.01) C07C 317/44 (2006.01) C07C 323/65 (2006.01) C07C 323/66 (2006.01) C07D 213/24 (2006.01) C07D 317/56 (2006.01)
Patent
CA 2170736
A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (III), wherein each of R1 and R2 is independently selected from alkyl, hydrido, hydroxyalkyl, halo, haloalkyl, alkoxycarbonyl and carboxyl; wherein R5 is selected from alkylsulfonyl, haloalkylsulfonyl and sulfamyl; and wherein B is phenyl or pyridyl, wherein B is optionally substituted at a substitutable position with alkyl, halo, alkylthio, cyano, haloalkyl, alkoxy, hydroxyalkyl and alkoxyalkyl; or a pharmaceutically-acceptable salt thereof.
Cette invention se rapporte à une classe de composés de 1,2-diarylcyclopentényle, ou à un sel pharmaceutiquement acceptable de ces composés, qui sont utiles pour traiter des inflammations et des troubles associés à des inflammations. Des composés particulièrement intéressants sont représentés par la formule (III), dans laquelle chacun des éléments R?1¿ et R?2¿ est choisi séparemment parmi alkyle, hydrido, hydroxyalkyle, halo, haloalkyle, alcoxycarbonyle et carboxyle; R?5¿ est choisi parmi alkylsulfonyle, haloalkylsulfonyle et sulfamyle; et B représente phényle ou pyridyle, B étant éventuellement substitué en une position substituable par alkyle, halo, alkylthio, cyano, haloalkyle, alcoxy, hydroxyalkyle et alcoxyalkyle.
Li Jinglin
Reitz David B.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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