1,2-diaza-dibenzoazulenes as inhibitors of tumour necrosis...

Details 1,2-diaza-dibenzoazulenes as inhibitors of tumour necrosis... 1,2-diaza-dibenzoazulenes as inhibitors of tumour necrosis...

C - Chemistry, Metallurgy

07

D

C07D 491/00 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2487015

The present invention relates to derivatives of 1,2-diaza-dibenzoazulene, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-(x (TNF-(x) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

L'invention concerne des dérivés de 1,2-diaza-dibenzoazulène, let es sels et les solvates pharmacologiquement acceptables de ceux-ci, des procédés et des intermédiaires permettant préparer ces dérivés, ainsi que leurs actions anti-inflammatoires, en particulier l'inhibition de la production de facteur de nécrose des tumeurs .alpha. (TNF-.alpha.) et l'inhibition de la production d'interleukine-1 (IL-1) ainsi que leur action analgésique.

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