1,2-dihydro-2-oxo-1,8-naphthyridine derivative

Details 1,2-dihydro-2-oxo-1,8-naphthyridine derivative 1,2-dihydro-2-oxo-1,8-naphthyridine derivative

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2456349

Hydrates of N-[1-butyl-4-[3-[3-(hydroxy)propoxy]-phenyl]-1,2-dihydro-2-oxo-1,8- naphthyridin-3-yl]-N'-(2,6- diisopropyl-4-aminophenyl)urea hydrochloride represented by the following formula [I] are more excellent in stability than amorphous one and are usable as more favorable drugs.

La présente invention concerne des hydrates d'hydrochlorure de N-[1-butyl-4-[3-[3-(hydroxy)propoxy]-phényle]-1,2-dihydro-2-oxo-1,8-naphtyridine-3-yle]-N'-(2,6-diisopropyle-4-aminophényl)urée représentés par la formule suivante (I). Ils se distinguent par une meilleure stabilité que les formes amorphes et sont d'un emploi plus intéressant comme médicaments.

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