1,2-dihydropyrazol-3-ones as cytokine mediators

Details 1,2-dihydropyrazol-3-ones as cytokine mediators 1,2-dihydropyrazol-3-ones as cytokine mediators

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4152 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61P 29/00 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2477091

The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, or enantiomeric and diasteriomeric forms or pharmaceutically acceptable salts thereof, have the formula: (A) wherein R is an ether or amino unit, R1 is substituted phenyl, each R2 and R3 unit is independently selected from the group consisting of: a) hydrogen; and b) substituted or unsubstituted C1-C10 hydrocarbyl selected from the group consisting of: i) C1-C10 linear, branched or cyclic alkyl; ii) C1-C10 aryl; iii) C1-C10 heterocyclic; iv) C1-C10 heteroaryl.

La présente invention concerne des composés qui peuvent empêcher la libération extracellulaire des cytokines inflammatoires, lesdits composés, ou les formes énantiomères ou diastériomères ou des sels pharmaceutiquement acceptables de ces derniers, et présentent la formule (A). Dans cette dernière, R est un éther ou une unité amino, R1 est un phényl substitué, chaque unité R2 et R3 est indépendemment sélectionnée dans le groupe se composant a) d' hydrogène, et b) d'hydrocarbyle C1-C10 substitué ou non substitué, sélectionné dans le groupe se composant de i) alkyle C1-C10 linéaire, ramifié ou cyclique; ii) aryle C1-C10 ; iii) hétérocyclique C1-C10; iv) hétéroaryle C1-C10.

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