1,2-dioxetane compounds as chemiluminescent labels for...

Details 1,2-dioxetane compounds as chemiluminescent labels for... 1,2-dioxetane compounds as chemiluminescent labels for...

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) C07D 207/46 (2006.01) C07D 321/00 (2006.01) C07D 407/12 (2006.01) C07D 495/04 (2006.01) C07F 7/18 (2006.01) C09K 11/07 (2006.01) G01N 33/53 (2006.01) G01N 33/533 (2006.01)

Patent

CA 2050076

ABSTRACT OF THE DISCLOSURE Dioxetanes which couple with organic and biological molecules of the formula: Image wherein X is a leaving group which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R1 is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.

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