1,2-disubstituted cyclic inhibitors of matrix...

Details 1,2-disubstituted cyclic inhibitors of matrix... 1,2-disubstituted cyclic inhibitors of matrix...

A - Human Necessities

61

K

A61K 31/4709 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 207/06 (2006.01) C07D 207/16 (2006.01) C07D 211/06 (2006.01) C07D 211/62 (2006.01) C07D 307/24 (2006.01) C07D 309/08 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2434044

The present application describes novel 1,2-disubsituted cyclic derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-8 membered non-aromatic ring consisting of: carbon atoms, 0-1 carbonyl groups, 0-1 double bonds, and from 0-2 ring heteroatoms selected from O, N, NR?2¿, and S(O)¿p? and the other variables are defined in the present specification, which are useful as metalloprotease and as TNF-.alpha. inhibitors.

L'invention concerne des dérivés cycliques à disubstitution en position 1,2, représentés par la formule I, y compris leurs sels pharmaceutiquement acceptables. Le cycle B est un cycle non aromatique de 3 à 8 chaînons, qui comprend: des atomes de carbone, 0 ou 1 groupe carbonyle, 0 ou 1 double liaison, et entre 0 et 2 hétéroatomes du cycle, pouvant être O, N, NR?2¿, et S(O)¿p?. Les autres variables sont telles que définies dans le corps de l'invention. Les dérivés considérés sont utiles comme inhibiteurs de métalloprotéase et de TNF alpha.

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