1,3,2-dioxathiolane oxide derivative

Details 1,3,2-dioxathiolane oxide derivative 1,3,2-dioxathiolane oxide derivative

C - Chemistry, Metallurgy

07

D

C07D 327/10 (2006.01) C07C 237/22 (2006.01) C07D 237/22 (2006.01) C07D 295/185 (2006.01) C07D 317/32 (2006.01) C07D 405/12 (2006.01) C07D 411/12 (2006.01)

Patent

CA 2047226

ABSTRACT OF THE DISCLOSURE A 1,3,2-dioxathiolane oxide derivative having good inhibitory activity against thiol proteases such as calcium- dependent neutral protease (CANP) and cathepsins B, H and L, which is expected to be used in the cure, mitigation, treatment and prevention of myotonic dystrophy, inflammation, and renal hypertension. This derivative is represented by the following formula:. Image [I] wherein X means -S(O)- or -S(O)2; R1 means a hydrogen atom, an alkali metal atom, a benzyl group, or a lower alkyl group; R2 means a lower alkyl group which may be substituted with a methylthio group, or a benzyl group, R3 and R4 may be the same or different and independently mean a hydrogen atom, an alkyl group having one to ten carbon atoms, a lower alkyl group substituted with a guanidyl group, a cycloalkyl group having 3 to 6 carbon atoms, a phenyl group, a benzyl group, or a phenethyl group, or together mean an alkylene group.

Affiliated with

Also associated with

Rating

1,3,2-dioxathiolane oxide derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,3,2-dioxathiolane oxide derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,3,2-dioxathiolane oxide derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1418792