1-(3,3,3,-triarylpropyl)-4-phenyl-4-piperidinemethanols

Details 1-(3,3,3,-triarylpropyl)-4-phenyl-4-piperidinemethanols 1-(3,3,3,-triarylpropyl)-4-phenyl-4-piperidinemethanols

C - Chemistry, Metallurgy

07

D

260/278.2, 260/2

C07D 211/22 (2006.01) A61K 31/395 (2006.01) A61K 31/445 (2006.01) C07C 57/38 (2006.01) C07C 57/72 (2006.01) C07D 209/52 (2006.01) C07D 209/70 (2006.01) C07D 211/52 (2006.01) C07D 211/64 (2006.01) C07D 211/96 (2006.01) C07D 217/04 (2006.01) C07D 221/22 (2006.01) C07D 223/04 (2006.01) C07D 295/00 (2006.01) C07D 333/08 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 1079734

ABSTRACT OF THE DISCLOSURE The present invention is concerned with 1-(3,3,3-triarylpropyl)-4-phenyl-4-piperidinemethanols. These compounds are prepared by reacting the appropriate piperidine esters or piperidine ester-amideswith a suitable hydride reducing agent in an organic solvent to give the compounds of the instant invention. The compounds of the instant invention possess potent anti-diarrheal utility as evidenced by their ability to inhibit gastro- lntestinal motility. These subject compounds also possess a very low degree of analgesia.

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