C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/266.1, 260/2
C07D 401/00 (2006.01) C07D 213/04 (2006.01) C07D 213/74 (2006.01) C07D 213/80 (2006.01) C07D 295/092 (2006.01) C07D 295/135 (2006.01) C07D 303/24 (2006.01)
Patent
CA 1124718
ABSTRACT OF THE DISCLOSURE The present invention provides 1-[3-(3,4,5-trimethoxy- phenoxy)-2-hydroxypropyl]-4-aryl piperazine derivatives. The derivatives have the formula Image in which R1 in a hydrogen atom, a C2 to C6-alkanoyl radical, 3,4,5-trimethoxy benzoyl radical, a nicotinoyl radical or a thienyl carbonyl radical and R2 represents a phenyl, naphthyl or pyridyl radical which may be substituted by the radicals R3 and R4, the radicals R3 and R4, which may be the same or different, each representing hydrogen, hydroxyl, fluorine, chlorine, bromine, a nitro group, a trifluoromethyl group, a C1 to C6-alkyl radical, a C1 to C6-alkoxy radical, a C1 to C6- alkyl thio radical, a C2 to C6-alkanoyl radical, an amino group, a C2-C6-alkanoyl-amino group, a C2-C6-alkanoyl-oxy group, a benzoyl-oxy group, a cyclohexyl-carbonyl-oxy group or a thienyl- carbonyl-oxy group, pharmaceutically acceptable, and to salts of their compounds. The compounds are pharmacodynamically active and show, for example, a pronounced anti-aggressive action together with neuroleptic properties, anti-convulsive and hypnotic effects being in evidence to a very limited extent only, if at all. In addition, the compounds show fever-reducing and oedema- inhibiting effects.
300288
Engel Jurgen
Jakovlev Vladimir
Kleemann Axel
Thiemer Klaus
Aktiengesellschaft Degussa
Marks & Clerk
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