(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane,...

Details (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane,... (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane,...

C - Chemistry, Metallurgy

07

D

C07D 209/52 (2006.01) A61K 31/40 (2006.01) A61K 31/403 (2006.01) A61K 31/407 (2006.01) A61K 45/06 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2434616

The present invention relates to (+)-1-(3,4-dichlorophenyl)-3- azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating of or preventing relapse of depression, anxiety disorders, eating disorders, or urinary incontinence in a patient comprising administering (+)-1-(3,4- dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof. The (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt therof is preferably substantially free of its corresponding (-)-enantiomer.

L'invention concerne (+)-1-(3,4-dichlorophényl)-3-azabicyclo[3.1.0]hexane et ses sels pharmaceutiquement acceptables, des compositions renfermant (+)-1-(3,4-dichlorophényl)-3-azabicyclo[3.1.0]hexane ou un sel pharmaceutiquement acceptable de celui-ci, ainsi que des procédés de traitement ou de prévention de rechute de dépression, de troubles d'angoisse, de troubles de l'alimentation, ou d'incontinence urinaire chez un patient, qui consistent à administrer (+)-1-(3,4-dichlorophényl)-3-azabicyclo[3.1.0]hexane ou un sel pharmaceutiquement acceptable de celui-ci. De préférence, (+)-1-(3,4-dichlorophényl)-3-azabicyclo[3.1.0]hexane ou le sel pharmaceutiquement acceptable de celui-ci, est sensiblement libre de son (-)-énantiomère correspondant.

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