1,3,4-oxadiazol-2(3h)-one derivatives, their preparation and...

C - Chemistry – Metallurgy – 07 – D

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C07D 271/113 (2006.01) A61K 31/42 (2006.01) C07D 413/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2136669

1,3,4-Oxadiazol-2(3H)-one derivatives, of formula Image (I) in which R1 represents either a hydrogen atom or a linear or branched (C1-4) alkyl group which is substituted with a hydroxyl group, a phenoxy group, a (C1-4)alkoxy group, a (C1-4)alkylthio group, a mercapto group, a (C1-4)alkoxy- (C1-4)alkoxy group, a di(C1-4)alkylamino group or an N-(C1-4)alkyl-N-propynylamino group, or represents a (C3-4)alkynyl group, and R2 either represents a linear or branched (C1-8)alkyl group which is substituted with one or more halogen atoms and/or a hydroxyl group, a 1-imidazolyl group or a 3-tetrahydropyranyl group, or represents a trifluoro (C3-5) alkenyl group, in the form of pure enantiomers or mixtures of enantiomers, including racemic mixtures, as well as the addition salts thereof with pharmaceutically acceptable acids, are useful as inhibitors of monoamine oxidase B.

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