1,3,4-oxadiazol-2-ones as ppar delta modulators and their...

Details 1,3,4-oxadiazol-2-ones as ppar delta modulators and their... 1,3,4-oxadiazol-2-ones as ppar delta modulators and their...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/4245 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2561230

The present invention is directed to 1, 3, 4-oxadiazalones, and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. The compounds of this invention are modulators of PPARdelta and therefore useful as pharmaceutical agents, especially for the treatment of demyelinating diseases and disorders of fatty acid metabolism and glucose utilization.

La présente invention a trait à des 1, 3, 4-oxadiazalones, et leurs sels pharmaceutiquement acceptables, des stéréoisomères, tautomères, ou solvates de ceux-ci. Les nouveaux composés comprennent ceux de la formule (I) dans laquelle les radicaux sont tels que définis dans la description. Les composés de la présente invention sont des modulateurs des PPAR delta et donc utiles en tant qu'agents pharmaceutiques pour le traitement de maladies de démyélinisation et de troubles de métabolisme des acides gras et de l'utilisation du glucose.

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