1,3,4-oxadiazole derivatives and their uses to treat diabetes

Details 1,3,4-oxadiazole derivatives and their uses to treat diabetes 1,3,4-oxadiazole derivatives and their uses to treat diabetes

C - Chemistry, Metallurgy

07

D

C07D 271/113 (2006.01) A61K 31/4245 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2747306

DGAT-1 inhibitor compounds of formula (I) and pharmaceutically-acceptable salts thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity (I) wherein n is 0, 1, 2 or 3, R is independently selected from fluoro, chloro, bromo, trifluoromethyl, methoxy, difluoromethoxy and trifluoromethoxy and Z is carboxy or a mimic or bioisostere thereof, hydroxyl, hydroxymethyl, or -CONRbRc wherein Rb and Rc are independently selected from hydrogen and (1-4C)alkyl, which (1-4C)alkyl group may be optionally substituted by carboxy or a mimic or bioisostere thereof.

La présente invention concerne des composés inhibiteurs de la DGAT-1 de formule (I) et de ses sels pharmaceutiquement acceptables, conjointement avec des compositions pharmaceutiques, leurs méthodes de fabrication et leur utilisation dans le traitement, par exemple, de l'obésité (I) dans laquelle n vaut 0, 1, 2 ou 3, R est choisi indépendamment parmi les groupes fluoro, chloro, bromo, trifluorométhyle, méthoxy, difluorométhoxy et trifluorométhoxy et Z représente un groupe carboxy ou l'un de ses mimes ou bio-isostères, hydroxyle, hydroxyméthyle, ou -CONRbRc où Rb et Rc sont choisis indépendamment parmi un atome d'hydrogène et un groupe alkyle en C1 à C4, lequel groupe alkyle en C1 à C4 peut être éventuellement substitué par un groupe carboxy ou l'un de ses mimes ou bio-isostères.

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