1,3,4-thiadiazole compounds as protein kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/10 (2006.01) A61K 31/433 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2583217

The invention relates to thiadiazole compound of formula (I), (see formula I) wherein R1, R2, R3, X, Y, m and n are as defined herein, useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

L'invention concerne des composés de thiadiazole que l'on utilise pour traiter des maladies médiées par la protéine kinase B (PKB). L'invention concerne également l'utilisation thérapeutique de ces composés de thiadiazole ainsi que leurs compositions dans le traitement d'états pathologiques associés à la croissance cellulaire anormale, au cancer, à des inflammations, et à des troubles métaboliques.

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