1,3,4,-thiadiazoles

Details 1,3,4,-thiadiazoles 1,3,4,-thiadiazoles

C - Chemistry, Metallurgy

07

D

167/208, 260/301

C07D 285/12 (2006.01) A61K 31/425 (2006.01) C07D 253/06 (2006.01) C07D 271/10 (2006.01) C07D 285/135 (2006.01) C07D 285/16 (2006.01) C07D 417/04 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/068 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1305286

Abstract There are described compounds of formula I, Image I in which Y is S, O or NR9, n is 0 or 1, R9 is hydrogen or alkyl C 1 to 10, R3 is hydrogen, alkyl C 1 to 10, cycloalkyl C3 to 10, CF3, SR10, a 5 or 6 membered heterocyclic group containing one or more S, O or N atoms, NR4R5, phenyl or phenylalkyl C7 to 12, the phenyl, phenylalkyl and heterocyclic groups optionally being fused to a further phenyl group, the heterocyclic group and any phenyl group optionally being substituted by alkyl C 1 to 6, halogen, alkoxy C 1 to 6, nitro, nitrile, CF3, SR6, NR7R11 or hydroxy, R6, R7 and R11, which may be the same or different, are each hydrogen or alkyl C 1 to 10, R4 and R5, which may be the same or different, are each hydrogen, alkyl C 1 to 10 or phenyl, R10 is alkyl C 1 to 10, X1 is S or O, and D is a chain comprising from 2 - 16 atoms, which chain carries an O or S containing substituent at a position 2 - 6 atoms away from the group C=X1, and pharmaceutically acceptable salts, esters and amides thereof, there are also described methods for making the compounds and pharmaceutical formulations, eg for the treatment of hypertension, containing them.

517181

Affiliated with

Also associated with

Rating

1,3,4,-thiadiazoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,3,4,-thiadiazoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,3,4,-thiadiazoles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1242497