1,(3,)5-substituted imidazoles, their use in the treatment...

Details 1,(3,)5-substituted imidazoles, their use in the treatment... 1,(3,)5-substituted imidazoles, their use in the treatment...

C - Chemistry, Metallurgy

07

D

C07D 233/60 (2006.01) C07D 233/61 (2006.01) C07D 233/64 (2006.01) C07D 233/66 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2687975

The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists suitable for transdermal delivery. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases.

L'invention concerne de nouveaux composés d'imidazole 1,5 et 1,3,5-substitutés, sous forme hydrophile ou lipophile, utiles en tant qu'antagonistes des récepteurs ATI de l'angiotensine II, pouvant être administrés par voie transdermique. L'invention concerne également des compositions pharmaceutiques contenant ces composés, des procédés et des intermédiaires pour leur préparation, ainsi que leur utilisation dans des méthodes de traitement de l'hypertension et des maladies cardiovasculaires.

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