1,3,5-triazine-2,4,6-triones, preparation and use as...

C - Chemistry – Metallurgy – 07 – D

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C07D 251/30 (2006.01) A61K 31/53 (2006.01) A61P 15/08 (2006.01) C07D 251/34 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 409/06 (2006.01) C07D 417/04 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2455833

GnRH receptor antagonists of formula I are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

La présente invention concerne des antagonistes du récepteur de GnRH représentés par la formule (I) qui sont utiles dans le traitement de diverses pathologies liées aux hormones sexuelles aussi bien chez l'homme que chez la femme. Cette invention concerne également des compositions contenant un composé selon l'invention en combinaison avec un support pharmaceutiquement acceptable, ainsi que des méthodes d'utilisation de ces dernières pour exercer un effet antagoniste sur la gonadolibérine chez un individu nécessitant un tel traitement. Formule (I)

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