C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/12 (2006.01) A61K 31/415 (2006.01) C07D 231/14 (2006.01) C07D 231/16 (2006.01)
Patent
CA 2234511
A compound of the formula (I) wherein R1 is hydroxyethyl, 1-hydroxy-1- methylethyl, hydrogen, halogen, nitro, or cyano, R2 is chloro, cyano, or lower alkyl optionally substituted with halogen, and R3 is lower alkylthio, lower alkylsulfinyl, or lower alkylsulfonyl, provided that when R1 is hydrogen, halogen, nitro, or cyano, then R2 is chloro, and a pharmaceutically acceptable salt thereof, processes for their preparation and pharmaceutical compositions.
Composé de la formule (I). Dans cette formule, R?1¿ est hydroxyéthyle, 1-hydroxy-1-méthyléthyle, hydrogène, halogène, nitro ou cyano; R?2¿ est chloro, cyano, ou alkyle inférieur facultativement substitué par halogène, et R?3¿ est alkylthio inférieur, alkylsulfinyle inférieur, ou alkylsulfonyl inférieur, sous réserve que, lorsque R?1¿ est hydrogène, halogène, nitro ou cyano, R?2¿ est chloro. L'invention porte également sur un sel pharmaceutiquement acceptable de ce composé, sur des procédés conçus pour leur préparation et sur des compositions pharmaceutiquement acceptables.
Harada Keiko
Matsuo Masaaki
Nakamura Katsuya
Nishimura Hiroaki
Noda Yuka
Fujisawa Pharmaceutical Co. Ltd.
Swabey Ogilvy Renault
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