1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/10 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2443868

The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G- protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition.

La présente invention concerne des nouveaux dérivés de 1,3,8-triazaspiro[4.5]decan-4-one représentés par la formule générale (I), dans laquelle toutes les variables sont telles que définies dans la description. Ces dérivés sont utiles dans le traitement de troubles et d'états pathologiques induits par le récepteur couplé à la protéine G ORL-1. Plus particulièrement, les composés de la présente invention sont utiles dans le traitement de troubles et d'états pathologiques tels que l'anxiété, la dépression, la toxicomanie, la douleur neuropathique, la douleur aiguë, la migraine, l'asthme et la toux, et pour améliorer les processus cognitifs.

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