1,3,8-triazaspiro¬4,5|decanone compounds as orl1-receptor...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/10 (2006.01) A61K 31/435 (2006.01) A61K 31/438 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) A61P 3/04 (2006.01) A61P 7/10 (2006.01) A61P 9/12 (2006.01) A61P 23/00 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/22 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2287054

A compound of the formula: (see formula I) R1 and R2 are independently C1-C4 alkyl; or R1 and R2, taken together with the carbon atom to which they are attached, form a mono-, bi-, tri- or spiro- cyclic group having 3 to 13 carbon atoms, wherein the cyclic group is optionally substituted by one to five substituents; A is (C1-C3)alkyl, phenyl, benzyl or the like; R is hydrogen, (C1-C3)alkyl, amino-(C1-C6)alkyl, heterocyclic-(C1-C3)alkyl wherein the heterocyclic is optionally substituted by amino, ((C1-C4)alkyl)-Z-(C1-C6)alkyl wherein Z is OC(=O) or the like; and X is (C1-C3)alkyl, phenyl or the like. These compounds are useful as ORL1-receptor agonists, and useful as analgesics or the like in mammalian subjects.

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