C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/4747 (2006.01) A61P 25/04 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01)
Patent
CA 2683598
The present invention is directed to novel 1.3.8-trisubstituted-1.3,8-triaza-spiro[4:5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. R3 is selected from the group consisting of R0 is selected from the group consisting of -CCH, hydroxy, -N3, -O-C(0)-C1-4 alkyl, -O-SO2-C1-4 alkyl, -O-(2- tetrahydropyranyl); wherein R1 is 1-ace.pi.a.rho.hthenyl; R2 is 4-fluorophenyl; A1 is selected from the group consisting of -CH2-,-CH2CH2-,-CH2CH2- and -CH2CH2CH2CH2
L'invention concerne de nouveaux dérivés de 1,3,8-trisubstitué-1,3,8-triaza-spiro[4:5]décan-4-one, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement de troubles et d'états médiés par le récepteur couplé à la protéine G ORL-1. R3 est choisi dans le groupe composé de : R0 est choisi dans le groupe composé de : -CCH, hydroxy, -N3, -O-C(0)-C1-4 alkyle, -O-SO2-C1-4 alkyle, -O-(2- tétrahydropyranyle); R1 étant 1-acénaphthényle; R2 étant 4-fluorophényle; A1 étant choisi dans le groupe composé de -CH2-,-CH2CH2-,-CH2CH2- et de -CH2CH2CH2CH2
Bignan Gilles C.
Hlasta Dennis J.
Ryan Richard R.
Janssen Pharmaceutica Nv
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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