1,3-benzothiazinone derivatives and the use thereof

Details 1,3-benzothiazinone derivatives and the use thereof 1,3-benzothiazinone derivatives and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/5415 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) A61P 43/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2459224

Compounds represented by the following general formula (I) or salts thereof: (I) wherein R1 represents hydrogen, halogeno, hydroxy, nitro, optionally halogenated alkyl, optionally substituted alkoxy, acyl or optionally substituted amino; R2 represents pyridyl, furyl, thienyl, pyrolyl, quinolyl, pirazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each optionally substituted; and n is 1 or 2; and preventives/remedies, which contain the compounds of the general formula (I) and have a high safety and favorable effects of inhibiting cell death and binding to MIF, for heart diseases, neurodegenerative diseases, brain vascular diseases, central nerve infections, traumatic diseases, demyelinating diseases, bone/joint diseases, kidney diseases, liver diseases, myelodysplastic syndrome, AIDS, cancer, etc.

L'invention concerne des composés de formule (I) ou des sels de ces composés. Dans cette formule, R?1¿ représente hydrogène, halogéno, hydroxy, nitro, alkyle éventuellement halogéné, alcoxy éventuellement substitué, amino acyle, ou éventuellement substitué; R?2¿ représente pyridyle, furyle, thiényle, pyrolyle, quinolyle, pyrazinyle, pyrimidinyle, pyridazinyle, indolyle, tétrahydroquinolyle ou thiazolyle, chacun de ces éléments étant éventuellement substitué; et n représente 1 ou 2. L'invention concerne des médicaments préventifs/remèdes contenant les composés de formule (I) et présentant des effets bénéfiques et très fiables pour l'inhibition de la mort cellulaire et pour la liaison à MIF, pour des maladies cardiaques, des maladies neuro-dégénératives, des maladies cérébrovasculaires, des infections du système nerveux central, des maladies traumatiques, des maladies de démyélinisation, des maladies osseuses/articulaires, des maladies rénales, des maladies du foie, le syndrome myélodysplasique, le SIDA, le cancer etc

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