1,3-benzoxazolyl derivatives as kinase inhibitors

Details 1,3-benzoxazolyl derivatives as kinase inhibitors 1,3-benzoxazolyl derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/423 (2006.01) A61P 35/00 (2006.01) C07D 263/58 (2006.01)

Patent

CA 2539767

The invention relates to compounds of formula 1, the production and use thereof as a medicament for the treatment of diseases, particularly tumours and/or diseases caused, mediated or propagated by angiogenesis. The compounds of formula 1 are effective inhibitors of tyrosin kinases, particularlyTIE-2 and VEGFR, and Raf-kinases. (I)

La présente invention concerne des composés de formule (I), leur production et leur utilisation pour produire un médicament servant à traiter des maladies, notamment des tumeurs et/ou des maladies engendrées, médiées et/ou propagées par angiogenèse. Les composés de formule (I) sont des inhibiteurs efficaces des tyrosine kinases, notamment de TIE-2 et de VEGFR, et des kinases Raf.

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