C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61K 31/221 (2006.01) A61K 31/24 (2006.01) A61K 31/4164 (2006.01) A61P 25/28 (2006.01) C07C 233/65 (2006.01) C07C 237/06 (2006.01) C07C 237/22 (2006.01) C07C 311/09 (2006.01) C07C 317/44 (2006.01) C07C 317/48 (2006.01) C07C 317/50 (2006.01) C07C 321/14 (2006.01) C07C 323/60 (2006.01) C07D 207/16 (2006.01) C07D 263/32 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2497979
The present invention relates to compounds of formula (AA), (I) and (X), useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
La présente invention concerne des composés de formule (AA), (I) et (X), utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies similaires. Lesdits composés comprennent des inhibiteurs de l'enzyme bêta-secrétase utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par un dépôt d'un peptide bêta amyloïde chez un mammifère. Les composés selon l'invention peuvent être utilisés dans des compositions pharmaceutiques et dans des méthodes de traitement destinées à réduire la formation de peptides bêta-amyloïdes.
Fobian Yvette M.
Freskos John N.
Jagodzinska Barbara
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company Llc
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