1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis...

Details 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis... 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/55 (2006.01) A61P 29/00 (2006.01) C07D 235/02 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01)

Patent

CA 2487017

The present invention relates to 1,3-diaza-dibenzoazulene derivatives of formula (I), to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-.alpha. (TNF-.alpha.) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

L'invention concerne des dérivés de classe de 1-thia-3-aza-dibenzoazulène représentés par la formule (I). L'invention concerne également des sels et des solvates de ces dérivés acceptables sur le plan pharmacologique, des procédés et des intermédiaires destinés à la préparation de ces dérivés ainsi que leurs effets anti-inflammatoires, notamment l'inhibition de production du facteur de nécrose tumorale .alpha. (TNF-.alpha.) et l'inhibition de production d'interleukine-1 (IL-1), ainsi que leur action analgésique.

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