1,3-dibenzoic acid esters of 17.alpha.-ethynyl-7.alpha.-...

Details 1,3-dibenzoic acid esters of 17.alpha.-ethynyl-7.alpha.-... 1,3-dibenzoic acid esters of 17.alpha.-ethynyl-7.alpha.-...

C - Chemistry, Metallurgy

07

J

260/46

C07J 5/00 (2006.01) C07J 1/00 (2006.01)

Patent

CA 1123426

ABSTRACT OF THE DISCLOSURE Novel 1,3-dibenzoic acid esters of 17.alpha.-ethynyl-7.alpha.- methyl-.DELTA.1,3,5(10)-oestratriene-1,3,17.beta.-triol and their manufacture by esterification of the corresponding free triol. The novel esters possess strong oestrogenic and ovulation-inhibiting activities, and in comparison with the corresponding diacetic acid esters remain stable under a thermal stress of up to 60°C over a period of 2 to 7 months, even in the desired low dosage amounts. The novel esters may accordingly be made up with suitable carriers and also, if desired, gestagens into pharmaceutical preparations, and, furthermore, with gestagens may be used as contraceptives.

325941

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