1,3-diheterocyclic metalloprotease inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/04 (2006.01) A61K 31/495 (2006.01) C07D 233/02 (2006.01) C07D 233/38 (2006.01) C07D 239/06 (2006.01) C07D 239/10 (2006.01) C07D 243/04 (2006.01) C07D 265/06 (2006.01) C07D 265/14 (2006.01) C07D 277/06 (2006.01) C07D 279/06 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 487/04 (2006.01) C07D 495/10 (2006.01)

Patent

CA 2264266

The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically- acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

L'invention concerne des composés représentés par la formule (I), tels qu'ils sont décrits dans les revendications, ou un de leurs isomères, diastéréomères ou énantiomères optiques, ou un de leurs sels acceptable sur le plan pharmaceutique, de leurs amides, esters ou imides biohydrolysables, utiles en tant qu'inhibiteurs de métalloprotéases. Elle concerne également des compositions pharmaceutiques et des procédés servant à traiter des maladies, des troubles et des états caractérisés par l'activité de métalloprotéases au moyen de ces composés ou des compositions pharmaceutiques les contenant.

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