1,3-dihydro-2h-imidazo(4,5-b) quinolin-2-one derivatives

Details 1,3-dihydro-2h-imidazo(4,5-b) quinolin-2-one derivatives 1,3-dihydro-2h-imidazo(4,5-b) quinolin-2-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/695 (2006.01) C07D 215/38 (2006.01) C07D 233/76 (2006.01) C07D 233/78 (2006.01) C07D 233/96 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 403/12 (2006.01) C07D 409/10 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2121230

Novel 1,3-dihydro-2H-imidazo(4,5-b)quinolin-2-one derivatives of formu- la (I) wherein R is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl optionally sub- stituted with from 1 to 3 substituents each independently selected from halo, hydroxy, C1-6alkyloxy, C5-6cycloalkyloxy, C1-6alkyl or trifluoromethyl; pyr- idinyl; thienyl optionally substituted with halo or C1-6alkyl; and (.alpha.) is a radi- cal of formula (a), (b), or (c); the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, said compounds being potent inhibitors of both phosphodiesterase III and IV, which are useful in the treatment of aller- gic disorders, atopic diseases and related afflictions. Intermediates in the prepar- ation thereof. Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions.

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