1,3-dihydro-6-¬1-cyano-1-isopropyl-n-phenethyl-n-methyl-...

Details 1,3-dihydro-6-¬1-cyano-1-isopropyl-n-phenethyl-n-methyl-... 1,3-dihydro-6-¬1-cyano-1-isopropyl-n-phenethyl-n-methyl-...

C - Chemistry, Metallurgy

07

D

167/231, 260/276

C07D 491/048 (2006.01) A61K 31/44 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1300151

A B S T R A C T This invention relates to new 1,3-dihydro-6- [l-cyano-l- isopropyl-N-phenethyl-N-methyl- .omega. -aminoalkyl] -7-hydroxy-furo- (3,4-c)-pyridine deriva- tives of the general formula Image wherein, each of A1 and A2 independently represents various substituents and to pharmaceutically acceptable salts of said derivatives, to a process for the preparation of the same, comprising reacting, in stoichiometric proportions, at 15-65°C, in dimethylsulphoxide, a 6-(l-cyano-2-methyl-propyl)- 7-hydroxy-furo-(3,4-c)-pyridine derivative with the appropriate N-methyl-N-phenethyl- .omega. -aminoalkyl choride and, finally, to a therapeutic composition of matter comprising as an essential ingredient therein an effective amount of any of said compounds together with an appropriate diluent or carrier.

493657

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