1,3-dihydro-6-(1-hydroxy-2-dimethylaminomethyl-allyl)-7-...

Details 1,3-dihydro-6-(1-hydroxy-2-dimethylaminomethyl-allyl)-7-... 1,3-dihydro-6-(1-hydroxy-2-dimethylaminomethyl-allyl)-7-...

C - Chemistry, Metallurgy

07

D

167/231, 260/276

C07D 491/048 (2006.01) A61K 31/44 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1300148

A B S T R A C T This invention relates to new 1,3-dihydro-6-(1- hydroxy-2- dimethylaminomethyl- allyl) -7-hydroxy-furo-(3,4-c) -pyridine derivatives of the general formula : Image wherein, each of A1 and A2 independently, represents various substituents, to a process for the preparation of these compounds comprising reacting a 6-formyl-7-benzyloxy- furo-(3,4-c)-pyridine derivative of the general formula II Image II with l-dimethylaminomethyl-vinylmagnesium bromide at the boil, in a non polar solvent and hydrolysing the 7-benzyloxy group and to a therapeutic composition of matter, comprising as an essential ingredient therein, at least one of these compounds.

473302

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