1, 3-dihydroimidazole-2-thione derivatives as inhibitors of...

Details 1, 3-dihydroimidazole-2-thione derivatives as inhibitors of... 1, 3-dihydroimidazole-2-thione derivatives as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/4178 (2006.01) A61P 25/22 (2006.01)

Patent

CA 2686387

Compounds of formula I and a method for their preparation are described, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies -alkyl-aryl or alkyl heteroaryl;X signifies CH2, oxygen atom or sulphur atom; n is 2 or 3; including the individual (R)- and (S)-enantiomers or mixtures of enantiomers thereof; and including pharmaceutically acceptable salts and esters thereof. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.

L'invention porte sur des composés de formule I et sur un procédé pour les préparer, où R1, R2 et R3 sont identiques ou différents et représentent hydrogènes, halogènes, un groupe alkyle, nitro, amino, alkylcarbonylamino, alkylamino ou dialkylamino; R4 représente -alkyl-aryle ou alkyl hétéroaryle; X signifie CH2, un atome d'oxygène ou un atome de soufre; n vaut 2 ou 3; y compris les énantiomères (R) et (S) individuels ou des mélanges d'énantiomères; et comprenant des sels pharmaceutiquement acceptables et des esters de ceux-ci. Les composés ont des propriétés pharmaceutiques potentiellement de valeur pour le traitement de troubles cardiovasculaires tels que l'hypertension et l'insuffisance cardiaque chronique.

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