1,3-dioxan-5-ylalkenoic acids

Details 1,3-dioxan-5-ylalkenoic acids 1,3-dioxan-5-ylalkenoic acids

C - Chemistry, Metallurgy

07

D

167/244, 260/351

C07D 319/04 (2006.01) A61K 31/335 (2006.01) C07D 319/06 (2006.01) C07D 319/08 (2006.01) C07D 407/04 (2006.01)

Patent

CA 1258464

ABSTRACT 1,3-Dioxan-5-yl-alkenoic Acids The invention concerns novel 4-phenyl-1,3-dioxan-5-ylalkenoic acid derivatives of the formula I having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and optionally substituted aryl or arylalkyl, Rc is hydroxy, alkoxy or alkanesulphonamido, n is 1 or 2, A is ethylene or vinylene, Y is (2-5C)polymethylene optionally substituted by alkyl, and benzene ring B is optionally substituted phenyl, or, when Rc is hydroxy, a salt thereof. The acid derivatives antagonise one or more of the actions of thromboxane A2 (TXA2) and are expected to be of value in those disease conditions in which TXA2 is involved. The invention also provides pharmaceutical compositions containing an acid derivative of formula I, and processes for their chemical production.

427937

Affiliated with

Also associated with

Rating

1,3-dioxan-5-ylalkenoic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,3-dioxan-5-ylalkenoic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,3-dioxan-5-ylalkenoic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1220601