C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/306.1
C07D 209/48 (2006.01)
Patent
CA 1051905
ABSTRACT OF THE DISCLOSURE A multistep process is disclosed for the production of a compound of the formula V: Image V wherein R' and R" are alkyl of 1 to 3 carbon atoms, inclusive or together Image is pyrrolidino, piperidino, 4-methylpiper- azino or morpholino; and wherein the rings A and B are unsub- stituted, or substituted by one or more substituents selected from the group consisting of fluoro, chloro, bromo, nitro and trifluoromethyl. Compounds of formula V are used for treatment of anxieties and/or depressions in mammals and birds. This divisional application is directed to the production of inter- mediate compounds of the formula II: Image wherein R1 is hydrogen or halogen. The process comprises treating one mole of a compound of the formula Image in an inert organic solvent with two mole equivalents of .alpha.-phthalimidoacetyl chloride or bromide in the presence of a base at -5° to 15°C.
310228
Gall Martin
Hester Jackson B. (jr.)
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