1,3-disubstituted 2-oxindoles as analgesic and anti-...

Details 1,3-disubstituted 2-oxindoles as analgesic and anti-... 1,3-disubstituted 2-oxindoles as analgesic and anti-...

C - Chemistry, Metallurgy

07

D

167/208, 260/207

C07D 209/34 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) C07D 207/24 (2006.01) C07D 209/00 (2006.01) C07D 209/04 (2006.01) C07D 209/42 (2006.01) C07D 209/58 (2006.01) C07D 209/60 (2006.01) C07D 209/70 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 407/06 (2006.01) C07D 407/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 491/02 (2006.01) C07D 491/048 (2006.01) C07D 491/056 (2006.01) C07D

Patent

CA 1255657

1,3-DISUBSTITUTED 2-OXINDOLES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS Abstract Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and anti- inflammatory agents in mammalian subjects. These 2- oxindole-1-carboxamide compounds are of particular value for acute administration for ameliorating pain in human patients recovering from surgery or trauma, and also for chronic administration to human subjects for alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis. Certain 2-oxindole-1-carboxamide compounds unsubstituted at C-3, but having an acyl substituent on the carbox- amide nitrogen atom, are useful as intermediates to the aforementioned analgesic and anti-inflammatory agents.

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