1,3-disubstituted-4-phenyl-1h-pyridin-2-ones

Details 1,3-disubstituted-4-phenyl-1h-pyridin-2-ones 1,3-disubstituted-4-phenyl-1h-pyridin-2-ones

C - Chemistry, Metallurgy

07

D

C07D 213/64 (2006.01) A61K 31/47 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2698929

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors - subtype 2("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

La présente invention concerne de nouveaux composés, notamment de nouveaux dérivés de pyridinone selon la formule (I), dans laquelle tous les radicaux sont tels que définis dans la demande et les revendications. Les composés selon l'invention sont des modulateurs allostériques positifs des récepteurs métabotropiques de sous-type 2 (mGluR2) qui sont utiles pour le traitement ou la prévention de troubles neurologiques et psychiatriques associés à une dysfonction du glucamate et de maladies qui impliquent le sous-type mGluR2 des récepteurs métabotropiques. De telles maladies sont notamment les troubles du système nerveux central sélectionnés dans le groupe constitué de l'anxiété, la schizophrénie, la migraine, la dépression et l'épilepsie. L'invention concerne également des compositions pharmaceutiques et des procédés de préparation de tels composés et de telles compositions, ainsi que l'utilisation de tels composés pour la prévention et le traitement de telles maladies qui impliquent mGluR2.

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