1,3-disubstituted imidazoles and a process for their production

Details 1,3-disubstituted imidazoles and a process for their production 1,3-disubstituted imidazoles and a process for their production

C - Chemistry, Metallurgy

07

D

260/315.25

C07D 233/60 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1184185

ABSRACT OF THE DISCLOSURE This invention discloses novel 1,3-disubstituted imidazoles of the general formula (I) Image (I) wherein A and B may be the same or different, and each is a straight- or branched-chain alkylene or alkenylene group having 1 to 8 carbon atoms, Y is an acyl group having 2 to 10 carbon atoms, an alkoxycarbonyl group having 2 to 7 carbon atoms or an dialkoxymethyl group having 3 to 13 carbon atoms, Z is a cyano group or an alkoxycarbonyl group having 2 to 7 carbon atoms, X is a halogen atom, n is zero or 1. These compounds are useful as intermediates for producing the imidazole derivatives of the general formula (V) Image (V) wherein A and B are defined herebefore, zl is a carboxyl group or an alkoxycarbonyl group,n is zero or 1 which pos- sess strong and specific inhibitory effects on thromboxane synthetase and thus are useful as therapeutical agents for treatment of diseases caused by thromboxane A2.

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