1,3-disubstituted pyrrolidines as alpha-2-adrenoceptor...

Details 1,3-disubstituted pyrrolidines as alpha-2-adrenoceptor... 1,3-disubstituted pyrrolidines as alpha-2-adrenoceptor...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/4025 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) C07D 207/06 (2006.01) C07D 207/08 (2006.01) C07D 207/09 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/08 (2006.01) C07D 405/12 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2398794

The invention provides compounds of formula (I) wherein R0, R1, R2 and A are as defined in the description, and the preparation thereof. The compounds of formula (I) have high affinity as .alpha.2 adreno-ceptors and hence are useful as pharmaceuticals.

L'invention concerne des composés de formule (I) dans laquelle R0, R1, R2 et A sont tel que définis dans la description, et leur préparation. Les composés de formule (I) présentent une affinité élevée en tant que récepteurs adrénergiques alpha 2 et sont donc utiles en tant que produits pharmaceutiques.

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