C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 267/06 (2006.01) A61K 31/551 (2006.01) A61K 31/553 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 243/04 (2006.01) C07D 401/04 (2006.01) C07D 401/10 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 409/10 (2006.01)
Patent
CA 2714532
This invention relates to novel compounds of the Formula (I)1 (I*), (I**), (Ia), (Ib), (Ic), (Id), (Ie)1 (If), (Ig), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 .beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Cette invention concerne de nouveaux composés des formules (I)1 (I*), (I**), (Ia), (Ib), (Ic), (Id), (Ie)1 (If), (Ig), leurs sels pharmaceutiquement acceptables et leurs compositions pharmaceutiques, qui sont utiles pour le traitement thérapeutique de maladies associées à la modulation ou à l'inhibition de 11ß-HSD1 chez les mammifères. L'invention concerne en outre des compositions pharmaceutiques des nouveaux composés, et des méthodes d'utilisation de ces composés pour réduire ou réguler la production du cortisol dans une cellule ou pour inhiber la conversion du cortisone en cortisol dans une cellule.
Claremon David A.
Singh Suresh B.
Tice Colin M.
Ye Yuanjie
Zhuang Linghang
Gowling Lafleur Henderson Llp
Vitae Pharmaceuticals Inc.
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