1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and...

Details 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and... 1-(3'-substitued-2', 3'-dideoxy-d-ribofuranosyl) thymine and...

C - Chemistry, Metallurgy

07

D

167/202, 167/218

C07D 239/54 (2006.01) A61K 31/70 (2006.01) C07H 19/06 (2006.01) C07H 19/073 (2006.01)

Patent

CA 1336088

A compound of the formula Image wherein the radicals A, X, R1, R2, and R3 are defined as follows: A : (a) Image or (b) Image X : (a) O (b) S (c) CH2 R1: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; Image ; -C?CH R2: H; or R2 constitutes together with R3 a carbon - carbon bond R3: H; F; Cl; Br; I; N3; CN; C?CH; OH; OCH3; CH2OH; and when R3 is F; Cl, Br; I; N3 ; CN; C?CH; OH; OCH3 or CH2OH it may have either the cis-configuration or trans-configuration relative to the hydroxymetyl function at position 4', or R3 constitutes together with R2 a carbon - carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.

580141

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