1, 3 substituted cycloamino derivatives and their use as...

Details 1, 3 substituted cycloamino derivatives and their use as... 1, 3 substituted cycloamino derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 401/10 (2006.01) A61K 31/402 (2006.01) A61K 31/4025 (2006.01) C07D 207/14 (2006.01) C07D 403/10 (2006.01) C07D 405/10 (2006.01) C07D 409/10 (2006.01)

Patent

CA 2574361

This invention is directed to compounds of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention- deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula (I) as described above.

L'invention se rapporte à des composés de la formule (I) définie ci-après, ou à un sel de ceux-ci pharmaceutiquement acceptable ; à une composition pharmaceutique contenant un composé de la formule I, à un procédé de traitement d'un trouble ou d'une condition pouvant être traités par antagonisation des récepteurs d'histamine H3, ce procédé consistant à administrer à un mammifère qui a besoin de ce traitement un composé de la formule (I) susmentionnée, et à un procédé de traitement d'un trouble ou d'une condition figurant dans le groupe dépression, troubles de l'humeur, schizophrénie, troubles d'anxiété, maladie d'Alzheimer, déficience de l'attention, hyperactivité avec déficit de l'attention, troubles psychotiques, troubles du sommeil, obésité, vertiges, épilepsie, mal des transports, maladies respiratoires, allergies, réactions des voies aériennes causées par une allergie, rhinite allergique, congestion nasale, congestion allergique, congestion, hypotension, maladies cardio-vasculaires, maladies de la voie gastro-intestinale, hyper et hypo mobilité, sécrétion acide de la voie gastro-intestinale, ce procédé consistant à administrer à un mammifère qui a besoin de ce traitement un composé de la formule (I) susmentionnée.

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