1-`(3r)-amino-4-(2-fluoro-phenyl)-butyl...

Details 1-`(3r)-amino-4-(2-fluoro-phenyl)-butyl... 1-`(3r)-amino-4-(2-fluoro-phenyl)-butyl...

C - Chemistry, Metallurgy

07

D

C07D 207/08 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/472 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) A61P 3/10 (2006.01) C07D 207/09 (2006.01) C07D 207/16 (2006.01) C07D 217/14 (2006.01) C07D 217/16 (2006.01) C07D 217/26 (2006.01) C07D 241/04 (2006.01) C07D 265/30 (2006.01)

Patent

CA 2576236

The invention relates to compounds of formula (I), wherein R1-9,Z, n, X, A, and Rb have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament for the treatment of type 2 diabetes mellitus, obesity and lipid disorders.

Cette invention concerne des composés de formule (I), dans laquelle R?1-9¿,?¿Z, n, X, A, et R?b¿ sont tels que définis dans le mémorandum descriptif et les revendications. Les composés de l'invention sont utiles comme inhibiteurs de la DPP-IV. L'invention concerne également la préparation desdits composés, ainsi que leur production et leur utilisation en tant que médicament destiné au traitement du diabète non insulino-dépendant, de l'obésité et des troubles lipidiques.

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